GeoVax Expands and Strengthens Intellectual Property Portfolio

Press Release

Filings Made in Corporate Focus Areas of SARS-CoV-2 and Immuno-OncologyAtlanta, GA – (NewMediaWire) – March 4, 2021 – GeoVax Labs, Inc. (NasdaqCM: GOVX) (“GeoVax” or the “Company”), a biotechnology company developing human immunotherapies and vaccines against infectious diseases and cancer, today announced the filing of two additional patent applications important to the Company’s key focus on vaccines against SARS-CoV-2 (COVID-19) and cancer immunotherapies.The Company has filed an International Patent Application under the Patent Cooperation Treaty to protect its proprietary COVID-19 vaccines based on its platform modified vaccinia Ankara (MVA) viral vector technology.  Unlike certain competitor vaccines that target only the COVID-19 spike protein, GeoVax’s vaccines are designed to provoke a response to multiple COVID-19 antigens, which are differentiated from competitive vaccines in that they may be less susceptible to viral mutations in the spike protein region that have emerged as problematic in multiple regions of the world. The Company’s vaccines are intended to be used as a primary vaccine or to boost COVID-19 vaccines from other companies as part of vaccination strategies to provide immunity to a range of SARS-CoV-2 variants.GeoVax also filed a U.S. patent application as part of its immunotherapy program, which covers updates in its innovative MVA viral vector technology to amplify an immune response to a cancer antigen in a patient via vaccination. Cancer vaccination is the subject of growing interest as a means to boost the body’s innate defense to cancer.David Dodd, GeoVax’s Chairman & CEO, commented, “These patent filings reflect our continued progress in advancing high-value development programs while seeking the strongest intellectual property portfolio possible.  We continue to develop and strengthen our assets within the two strategic areas of COVID-19 and immuno-oncology, with a focus on accelerating each towards clinical development.  With these filings, our wholly owned, co-owned, and in-licensed intellectual property portfolio now stands at over 70 granted or pending patent applications spread over 20 patent families. Over the past few months, we have successfully capitalized the Company, strengthened our balance sheet, expanded our IP portfolio and accelerated developments to upcoming important data milestones.  We look forward to further advancing our programs and continued growth in GeoVax value.”About GeoVaxGeoVax Labs, Inc. is a clinical-stage biotechnology company developing human vaccines against infectious diseases and cancer using a novel patented Modified Vaccinia Ankara-Virus Like Particle (MVA-VLP) based vaccine platform. On this platform, MVA, a large virus capable of carrying several vaccine antigens, expresses proteins that assemble into VLP immunogens in the person receiving the vaccine. The production of VLPs in the person being vaccinated can mimic virus production in a natural infection, stimulating both the humoral and cellular arms of the immune system to recognize, prevent, and control the target infection. The MVA-VLP derived vaccines can elicit durable immune responses in the host similar to a live-attenuated virus, while providing the safety characteristics of a replication-defective vector.GeoVax’s current development programs are focused on preventive vaccines against COVID-19, HIV, Zika Virus, hemorrhagic fever viruses (Ebola, Sudan, Marburg, and Lassa), and malaria, as well as therapeutic vaccines against multiple cancers. The Company has designed a preventive HIV vaccine candidate to fight against the subtype of HIV prevalent in the commercial markets of the Americas, Western Europe, Japan, and Australia; human clinical trials for this program are managed by the HIV Vaccine Trials Network (HVTN) with the support of the National Institutes of Health (NIH). GeoVax’s HIV vaccine is also part of two separate collaborative efforts to apply its innovative gene therapy approach toward a functional cure for HIV.About Modified Vaccinia Ankara (MVA)The creation of our MVA …